Physicochemical study on some cycloltexa peptide nano rings at body normal temperature; novel biodegradable and biocompadble vectors in drug delivery

نویسندگان

  • B. Khalili Hadad -
  • K. Parivar -
  • M. Sayadian -
  • P. Yaghmaei -
چکیده مقاله:

Nanopartmles have been used as an approach to improve the pharmacodynamic and phannacokinetie propertiesof various drues. Amino acids have been considered to be useful to make such nano particles because ofthocompatithe and biodegradable characteristic. The quantum mechanical method that was chosen to analyze inethio hexa peptide nano ring]. The structure of some peptide nanorrigs as well as their dipole moments andenergies have been studied by quantum chemical calculations within the Ousager self-consistent reaction field(SCRF) model zing a Hartree-Fock method (RHF) at the RIIF/STO-30 (5D-7F). Radius of Gyration, Dipolemoment and Ramachandnm Plot are obtained to analyze the physicochemical characteristics of eyelo hexapeptide nano rings. These rings are studied concerning the utilization as nanovehicles.

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physicochemical study on some cycloltexa peptide nano rings at body normal temperature; novel biodegradable and biocompadble vectors in drug delivery

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عنوان ژورنال

دوره 6  شماره 4

صفحات  49- 58

تاریخ انتشار 2010-02-01

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